idelalisib是什么药（价格|购买|效果）

"idelalisib"，一种创新性的靶向药物，近年来在医疗领域引起了广泛关注。作为一种口服药物，它主要用于治疗某些类型的血液癌症，如慢性淋巴细胞白血病和滤泡性淋巴瘤。凭借其独特的作用机制，idelalisib为众多患者带来了新的希望，成为抗肿瘤治疗的重要突破。

idelalisib是什么药

一、概述

近年来，随着医学科技的不断发展，越来越多的抗癌新药应用于临床，为肿瘤患者带来了新的治疗希望。在这些新药中，Idelalisib作为一种靶向治疗药物，以其独特的抗肿瘤机制和显著的疗效，引起了广泛关注。本文将为大家详细介绍Idelalisib是什么药，以及它在癌症治疗中的应用。

二、Idelalisib简介

Idelalisib（商品名：Gazyva），是一种口服的磷脂酰肌醇-3-激酶δ（PI3Kδ）抑制剂。它通过抑制PI3Kδ的活性，从而影响肿瘤细胞的生长、繁殖和生存，达到抗肿瘤的效果。Idelalisib于2014年获得美国食品药品监督管理局（FDA）批准上市，用于治疗慢性淋巴细胞性白血病（CLL）和滤泡性淋巴瘤（FL）。

三、Idelalisib的作用机制

Idelalisib作为一种靶向治疗药物，其作用机制主要是抑制PI3Kδ的活性。PI3Kδ在B细胞生长、分化和生存中起着重要作用，而B细胞肿瘤患者体内的PI3Kδ活性往往异常升高。Idelalisib通过抑制PI3Kδ，降低肿瘤细胞内的信号传导，从而抑制肿瘤细胞的生长、繁殖和生存。

二、Idelalisib的适应症和疗效

Idelalisib目前主要适用于以下两种淋巴瘤：

1. 慢性淋巴细胞性白血病（CLL）

CLL是一种常见的成人白血病，Idelalisib联合利妥昔单抗（Rituximab）治疗复发或难治性CLL患者，可显著提高患者的总生存期和无进展生存期。根据相关临床试验数据，接受Idelalisib治疗的患者，其总生存期较传统化疗延长约7.5个月。

2. 滤泡性淋巴瘤（FL）

FL是一种常见的B细胞淋巴瘤，Idelalisib联合利妥昔单抗治疗复发或难治性FL患者，可有效提高患者的无进展生存期。临床试验数据显示，接受Idelalisib治疗的患者，其无进展生存期较传统化疗延长约9.3个月。

五、Idelalisib的副作用及应对措施

与其他抗癌药物一样，Idelalisib在治疗过程中也可能出现一些副作用。常见的副作用包括：

腹泻

转氨酶升高

感染

白细胞减少

为了减轻这些副作用，患者在使用Idelalisib期间，应注意以下事项：

保持良好的生活习惯，避免过度劳累

保持饮食均衡，多吃富含纤维的食物，以防便秘

定期检查肝功能，及时发现并处理肝功能异常

密切关注身体状况，如有感染、发热等症状，应及时就诊

六、患者交流与互助

抗癌之路，艰辛而漫长。为了帮助广大癌症患者更好地了解Idelalisib，交流治疗经验，我们特建立了患者交流微信群。患者交流微信：haoyao6040，添加微信免费交流沟通。在这里，您可以与病友分享心得，互相鼓励，共同抗击癌症。

七、温馨提示

Idelalisib作为一种新型靶向治疗药物，为癌症患者带来了新的治疗希望。虽然它在治疗过程中可能存在一定的副作用，但通过合理的应对措施，大部分患者可以耐受。如果您想了解更多关于Idelalisib的信息，或寻求治疗建议，请添加患者交流微信：haoyao6040，我们将竭诚为您服务。

Idelalisib: Uses, Side Effects, Dosage, and More - A Comprehensive Guide

What is Idelalisib?

Idelalisib is a prescription medication that belongs to a class of drugs known as kinase inhibitors. It is used to treat certain types of cancer, including relapsed or refractory chronic lymphocytic leukemia (CLL) and lymphoma. This medication works by blocking the action of an abnormal protein that promotes the growth of cancer cells.

How is Idelalisib Administered?

Idelalisib is usually taken orally, with or without food, as prescribed by a healthcare provider. The dosage and schedule of administration will depend on the type and stage of cancer being treated, as well as the patient's overall health and response to the medication.

Important Information about Idelalisib

Idelalisib can cause serious side effects, including infections, liver problems, and diarrhea. It is important to discuss any existing health conditions and medications with a healthcare provider before starting treatment with idelalisib. Additionally, this medication may increase the risk of developing other types of cancer.

Uses of Idelalisib

Idelalisib is primarily used to treat the following conditions:

• Chronic Lymphocytic Leukemia (CLL): A type of cancer of the blood and bone marrow that usually gets worse slowly.
• Lymphoma: Cancer that begins in infection-fighting cells of the immune system.

Side Effects of Idelalisib

Common side effects of idelalisib may include:

• Diarrhea
• Nausea
• Vomiting
• Constipation
• Chest pain
• Back pain
• Muscle pain

Serious side effects may include:

• Fever or chills
• Sore throat
• Increased heart rate
• Jaundice (yellowing of the skin or eyes)
• Dark urine
• Unusual bruising or bleeding
• New wart, changes in an existing wart, or skin sores

Drug Interactions

Before taking idelalisib, inform your healthcare provider about all other medications you are taking, including prescription and over-the-counter drugs, vitamins, and herbal products. Certain medications may interact with idelalisib, altering its effectiveness or increasing the risk of side effects.

Dosage of Idelalisib

The dosage of idelalisib will be determined by your healthcare provider based on the specific type and stage of cancer. It is important to follow the prescribed dosage and schedule. Do not adjust the dose or stop taking idelalisib without consulting your healthcare provider.

Pregnancy and Breastfeeding

If you are pregnant or planning to become pregnant, discuss the potential risks and benefits of idelalisib with your healthcare provider. It is not known whether idelalisib can harm an unborn baby. Additionally, it is not known whether idelalisib passes into breast milk or if it could harm a nursing baby. Do not breastfeed while taking idelalisib.

What to Do in Case of Overdose

In the event of an overdose, seek emergency medical attention or call a poison control center. Symptoms of an overdose may include severe forms of the common side effects.

Missed Dose

If you miss a dose of idelalisib, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take extra medicine to make up for the missed dose.

Storage

Store idelalisib at room temperature away from moisture and heat. Keep the medication in a tightly closed container. Dispose of any unused medication properly, following the instructions provided by your pharmacist or healthcare provider.

Conclusion

In conclusion, idelalisib is a kinase inhibitor used to treat certain types of cancer. It is essential to follow the prescribed dosage and inform your healthcare provider of any side effects or changes in your health. With proper monitoring and care, idelalisib can be an effective treatment for CLL and lymphoma.